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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TNNI3K All Species: 11.82
Human Site: S835 Identified Species: 26
UniProt: Q59H18 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q59H18 NP_001106279.1 936 104179 S835 E L M S P A S S N S S G S L S
Chimpanzee Pan troglodytes XP_513493 949 105567 S848 E L M S P A S S N S S G S L S
Rhesus Macaque Macaca mulatta XP_001097254 949 105560 S848 E L M S P A S S N S S G S L S
Dog Lupus familis XP_537112 1087 119299 T986 P E F S E V V T K L E E C L C
Cat Felis silvestris
Mouse Mus musculus Q5GIG6 834 92569 N734 L M S P A S S N S S G S L S P
Rat Rattus norvegicus Q7TQP6 835 92713 N735 L M S P A S S N S S G S L S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001339957 835 92821 N735 L M S P A S S N S S G S L S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001021182 850 93167 Q750 L P N Q P T A Q F P A H I L S
Sea Urchin Strong. purpuratus XP_782227 862 95496 K762 Q E F L A V S K T L S G V L S
Poplar Tree Populus trichocarpa XP_002336079 539 60951 P439 P E V I E H K P Y D H K A D V
Maize Zea mays NP_001152032 543 61643 Y443 E I I N H K P Y D H K A D V F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 96.5 80.1 N.A. 80.7 81.3 N.A. N.A. N.A. N.A. 75.7 N.A. N.A. N.A. 36.7 51.1
Protein Similarity: 100 98.3 97.2 82.6 N.A. 84.4 85.3 N.A. N.A. N.A. N.A. 83.7 N.A. N.A. N.A. 55 65.6
P-Site Identity: 100 100 100 13.3 N.A. 13.3 13.3 N.A. N.A. N.A. N.A. 13.3 N.A. N.A. N.A. 20 33.3
P-Site Similarity: 100 100 100 20 N.A. 40 40 N.A. N.A. N.A. N.A. 40 N.A. N.A. N.A. 33.3 40
Percent
Protein Identity: 23.6 22.4 N.A. N.A. N.A. N.A.
Protein Similarity: 37.2 36.2 N.A. N.A. N.A. N.A.
P-Site Identity: 0 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 40 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 37 28 10 0 0 0 10 10 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % C
% Asp: 0 0 0 0 0 0 0 0 10 10 0 0 10 10 0 % D
% Glu: 37 28 0 0 19 0 0 0 0 0 10 10 0 0 0 % E
% Phe: 0 0 19 0 0 0 0 0 10 0 0 0 0 0 10 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 28 37 0 0 0 % G
% His: 0 0 0 0 10 10 0 0 0 10 10 10 0 0 0 % H
% Ile: 0 10 10 10 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 10 10 10 10 0 10 10 0 0 0 % K
% Leu: 37 28 0 10 0 0 0 0 0 19 0 0 28 55 0 % L
% Met: 0 28 28 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 10 0 0 0 28 28 0 0 0 0 0 0 % N
% Pro: 19 10 0 28 37 0 10 10 0 10 0 0 0 0 28 % P
% Gln: 10 0 0 10 0 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 28 37 0 28 64 28 28 55 37 28 28 28 46 % S
% Thr: 0 0 0 0 0 10 0 10 10 0 0 0 0 0 0 % T
% Val: 0 0 10 0 0 19 10 0 0 0 0 0 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 10 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _